Untreated hypertension leads to damage to organs and their function. There is a risk of ischemic heart disease, acute myocardial infarction, stroke, kidney failure, blindness or ischemic disease of the lower limbs, etc. Ischemic heart disease is among the diagnoses with the highest incidence in the population both in the Czech Republic and in the developed world. According to the current European recommendations for the diagnosis and treatment of hypertension, beta-blockers represent one of the five basic groups of antihypertensives, which are suitable for the initiation of therapy as well as long-term maintenance treatment of hypertension. Beta-blockers are the basis of therapy in patients after myocardial infarction and with angina pectoris. An in vivo rat model can be used to study the effectiveness of substances with a potential hypotensive effect. The project will aim to test substances synthesized by the Technical University of Rzeszów. These substances have already been tested at our workplace (UFTo) in cooperation with the ICRC-FNUSA for their antiarrhythmic effect on the suspended heart model. For selected substances with a proven hypotensive effect, the hypotensive and antiarrhythmic properties of their enantiomers would be further monitored. The project is in line with the long-term research plan of the faculty and deepens cooperation with research institutions at JMK (FNUSA ICRC Brno) and international cooperation with Rzeszow University of Technology (prof. Grazyna Groszek).

Sustainable Development Goals

Masaryk University is committed to the UN Sustainable Development Goals, which aim to improve the conditions and quality of life on our planet by 2030.

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